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Xenotransplantation is a potential solution to bridge the gap between donors and patients awaiting transplantation. In particular, pigs are considered as a suitable source of organs because they are anatomically and physiologically similar to humans and can supply many organs. However, Immunological barriers induced by differences in glycosylation between humans and mammals limit successful clinical trials of xenograft. Certain glycan structures such as Galactose-α-1,3-galactose, NeuGc, and SDa antigen act as antigens that trigger immune response. Despite the importance of glycan in the immune system, characterization of glycans expressed in donor pigs is still lacking. The AGRS is creating a comprehensive, organ, cell, and tissue-specific glycan database based on glyco-synthesis that can be used to identify potential xeno-glycan antigens.

Research highlights:
  • Comprehensive glycome profiling of organ, cell, and tissue-specific
  • Construction of porcine sample library (database)
  • Characterization of non-human glycan antigens
Relevant publications:
  • Choe, H.M., Luo, Z.B., Kang, J.D., Oh, M.J., An, H.J, Yin, X.J., “Pathological features in 'humanized' neonatal pig”, Anim Biotechnol, 2021, 1-9.
  • Seo, N., Ko, J., Lee, D., Jeong, H., Oh, M.J., Kim, U., Lee, D.H., Kim, J., Choi, Y.J., An, H.J., “ In-depth characterization of non-human sialic acid (Neu5Gc) in human serum using label-free ZIC-HILIC/MRM-MS”, Analytical and bioanalytical chemistry, 2021, 413(20), 5227-5237.
  • "In-depth Structural Analysis of Non-human Glycan Antigens for Xenotransplantation", 10th Asia-Oceania Human Proteome Organization Congress, 2021, Poster presentation.
  • "Revealing the Structure of Non-human Glycan Antigens in a Xenograft Model using Nano LC/MS/MS", 2021 Annual Meeting of the Korean Society for Glycoscience, 2021, Poster presentation.
  • "Structural Characterization of Non-human Glycan Antigens in a Xenograft Model using Nano PGC LC/MS/MS and Exoglycosidase Digestion", 128th General Meeting of the Korean Chemical Society, 2021, Poster presentation.